How to Take DoxyPEP: A Guide to Ensure Proper Application

‍In the field of sexual health, preventive measures play a crucial role in minimizing the risk of sexually transmitted infections (STIs). DoxyPEP is a potential important new medical preventive measure due to its estimated effectiveness. As DoxyPEP is an antibiotic-based prescription medication, it is essential that it is only used in appropriate risk groups after certain exposure. Below we go into the details of how DoxyPEP is taken.
February 19, 2024

Disclaimer: Please note that this information is provided for general informational purposes only and is not a substitute for professional medical advice or consultation. Each individual's health situation is unique and has to be decided case by case. It is important to seek the guidance of a qualified healthcare provider for any questions or decisions regarding the use of DoxyPEP or any other medical treatments. If you are considering DoxyPEP for yourself, we recommend contacting your health practitioner or finding one through Every Health for personalized advice and care.

Dosage and Timing

DoxyPEP involves taking a single 200mg pill of doxycycline, a broad-spectrum antibiotic, not later than 72hours (three days) after a sexual contact. A prompt administration is key to maximizing the effectiveness of DoxyPEP in preventing the transmission of STIs. However, it can also make sense to take just one pill for the entire weekend on Sunday or Monday morning.

Taking PREP or DoxyPEP is not the full game, you have to know when you can be lax and when you're really jeopardizing efficacy.

Well-Tolerated with Proper Intake

One of the positive aspects of DoxyPEP is its overall good tolerance by users. To enhance the experience and reduce the potential for side effects, it is recommended to take DoxyPEP with a full glass of water and stay upright for half an hour. Importantly, it should not be taken on an empty stomach. These simple steps help to minimize the risk of gastrointestinal side effects that can be associated with this antibiotic. Concerning long-term effects on microbiota and bacterial resistances, we are still learning, even though we have good experience with the long-term use of Doxycycline in other medical fields.

Avoidance of Certain Substances

For optimal effectiveness, it's crucial to avoid taking supplements or consuming foods rich in calcium, magnesium, or aluminum salts at the same time as DoxyPEP. This includes popular items such as dairy products, stomach remedies, fitness drinks, and electrolytes. These substances, if ingested concurrently, can interfere with the absorption of doxycycline, potentially reducing the efficacy of DoxyPEP. It is recommended to wait at least 4 hours after taking DoxyPEP before consuming these items.

Although sun is not a substance, you should wear good sun protection for 3 days after taking DoxyPEP, otherwise you run the risk of getting sunburn due to a photoxic effect.

Intake Frequency

To prevent misuse and potential complications, DoxyPEP should not be taken more than once within a 24-hour period.  Adhering to this guideline is essential to ensure the safe and effective use of DoxyPEP without exceeding the prescribed dosage.

Well planned, one dose on Monday can last for the entire last weekend and your gut microbiota will be very grateful for the smaller dose.

Additional Considerations

While DoxyPEP is a powerful tool in STI prevention, individuals should be aware that it does not protect against HIV or other STIs. Therefore, it is crucial to continue practicing safe sex practices and, if applicable, use additional preventive measures. If symptoms occur that could indicate an STI, DoxyPEP should not be taken until a qualified STI test has ruled out a bacterial STI.

It's also essential to consult with healthcare professionals before taking DoxyPEP, especially if there are any pre-existing health conditions or concerns about potential interactions with other medications.

If there is a risk of pregnancy, you should not take DoxyPEP as it can damage the bones and teeth of the unborn child. If you later find out that you were already pregnant while taking DoxyPEP, don’t panic. It is unlikely that doxycycline will harm your unborn within the first 3 months of pregnancy. No DoxyPEP should be taken while breastfeeding.


Proper administration of DoxyPEP is paramount for its efficacy in preventing the transmission of STIs. By understanding the recommended dosage, timing, and potential interactions with certain substances, individuals can confidently incorporate DoxyPEP into their sexual health toolkit if it recommended. As with any medication, consulting with healthcare professionals ensures personalized guidance and enhances the overall effectiveness of this innovative preventive measure.