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Your STI prevention plan membership
Your membership includes:



Starting at €25/month. Cancel anytime.
Plan D is helping people take charge of their sexual health
Supported by leading clinical research
What is it?
Condoms are a great tool for STI risk reduction, but they're not for everyone. For some, certain medications can serve as an effective alternative or additional layer of protection. If used correctly, these medications significantly reduce the likelihood of contracting chlamydia and syphilis, and to a lesser degree, gonorrhea.
Subject to recommendation and prescription by a doctor, medication based STI risk reduction involves taking a one-time, single dose of an antibiotic to reduce the risk of contracting an STI after a sexual contact. If the antibiotic is taken once, no later than 72 hours after sex, it can lower the risk of contracting an STI significantly according to medical research.
Based on clinical studies, medication based STI prevention can be beneficial for cisgender men who have condomless sex with men (MSM) and trans* individuals (AMAB) who have sex with MSM. Condomless sex means that a condom isn’t used for most of the time. That can be during any type of sex - oral, anal, and vaginal or front-hole sex.
Currently, research and studies focus on these particular groups. However, there may be some individual cases in which a doctor can deem medication based STI prevention appropriate for individuals outside of the outlined groups.
There’s plenty. Clinical studies compiled by the German STI Society provide valuable insight into the efficacy of medication-based prophylaxis against multiple STIs. According to these studies, it demonstrates significant efficacy in reducing the transmission of some of the most common STIs:
1. Syphillis reductions: 73-87%
2. Chlamydia reductions: 70-89%
3. Gonorrhea reductions: 17-57%
Field data from clinics that already prescribe medication-based STI prevention confirm the efficacy shown in these studies.
Some sources include:
- Molina JM et al. Lancet Infect Dis. 2018; 18(3):308-17
- Luetkemeyer AF et al. N Engl J Med. 2023; 388(14):1296-306
- Molina JM et al. CROI 2024; Abstr 174
- Bolan RK et al. Sex Transm Dis. 2015; 42(2):98-103.
- Scott H et al, CROI 2024 #126

How does it work?
Answer a few questions through our online questionnaire
Receive your treatment recommendation and prescription (if indicated) from a doctor within 12h*
Get your medication delivered next day* or pick it up at a pharmacy (if indicated)
Get regular medical check-ins and support when you need it. We're here for you.
FAQs
You can cancel Plan D any time.
If you are deemed medically unsuitable for Plan D, you will get your money back. This does not apply to the "Consultation + Paper Prescription" option.
We are always here for you: You receive regular medical check-ins and quick support whenever you need it, without long waiting times for an appointment.
If indicated, a doctor can prescribe a specific antibiotic that is taken once after sexual contact. When used within a maximum of 72 hours after sex, it can significantly reduce the likelihood of contracting chlamydia and syphilis and, to a lesser extent, gonorrhea.
Clinical studies show significant effectiveness in reducing the transmission of some of the most common STIs:
reduction in Chlamydia
Field data from clinics that already prescribe medication-based STI prevention confirm the effectiveness shown in these studies (Reduction of chlamydia: 67-90%, Reduction of syphilis: 56-78%).
Sources:
Molina JM et al. Lancet Infect Dis. 2018; 18(3):308-17
Luetkemeyer AF et al. N Engl J Med. 2023; 388(14):1296-306
Molina JM et al. CROI 2024; Abstr 174
Bolan RK et al. Sex Transm Dis. 2015; 42(2):98-103
Scott H et al, CROI 2024 #126
For chlamydia and syphilis, despite long-term use, no resistances against the standard therapies have been observed. Gonorrhea, on the other hand, already has high resistance, which is why the antibiotic used for STI-prophylaxis is not used for treatment; other antibiotics are typically used here. Moreover, there are currently no indications that the usual therapy for gonorrhea is compromised by medication-based STI-prophylaxis, as it does not seem to increase resistance to other antibiotics (Chu VT et al., CROI 2024, #1154).
For other bacteria, the development of resistance is relatively low with moderate use (Chu VT et al.; CROI 2024; #1154). But even with daily use, resistance build-up is limited and not permanent (Truong R et al. 2022; doi:10.1093/jacamr/dlac009).
Antibiotic resistance is a serious topic and should be monitored. However, when used responsibly and under medical supervision as post-exposure prophylaxis, major adverse effects are unlikely. This approach has proven to be highly effective in reducing the likelihood of STIs among at-risk individuals, such as gay men and trans women who engage in condomless sex.




You can cancel Plan D anytime.
Disclaimer: Please note that this information is for general informational purposes only and not a substitute for professional medical advice. Each individual's health situation is unique. Always use medication under medical supervision, following the prescribed instructions for optimal results and minimal side effects.
Our partner pharmacy is Leibniz Apotheke in Hannover (Georgstraße 46, 30159 Hannover). In case of questions regarding pharmaceuticals, please contact our partner pharmacy or a pharmacy of your choice.